Friday Night with Jonathan Ross is a British chat show presented by Jonathan Ross and broadcast on BBC One between 2001 and 2010. The programme features Ross' take on current topics of conversation, guest interviews (usually three per show) and live music from both a guest music group and the house band. First broadcast on 2 November 2001, the show began its final series in January 2010 and ended on 16 July 2010.

The most frequent guests were Ricky Gervais and Jack Dee (eight episodes each), Eddie Izzard (seven episodes), Jeremy Clarkson and Jimmy Carr (six episodes). Johnny Vegas, David Attenborough, Stephen Fry, Damon Albarn and Simon Pegg all appeared in five episodes and Robbie Williams appeared in four episodes.

From 2009 until its ending, the programme was broadcast in high definition on BBC HD. Studio TC4 in the BBC Television Centre in London, where the show was made, was upgraded to HD, making it the third television studio in Television Centre to be upgraded to HD (the others being Studios TC1 and TC8).

The show was pulled by the BBC on 29 October 2008 when Ross and Russell Brand were both suspended from their TV and radio shows in the events after The Russell Brand Show prank telephone calls row. The show returned on 23 January 2009, attracting 5.1 million viewers. The final 275th episode was broadcast on 16 July 2010.

On 12 June 2009, the show began airing in the United States on BBC America at 8pm EST. In 2010, it also started airing on the UKTV channel in Australia, just weeks after the episodes were first aired in the UK.

In June 2010, it was announced that Ross would be moving to ITV to host a new Saturday night chat show, The Jonathan Ross Show, which started airing in September 2011.