OS/2 (Operating System/2) is a series of computer operating systems, initially created by Microsoft and IBM under the leadership of IBM software designer Ed Iacobucci. As a result of a feud between the two companies over how to position OS/2 relative to Microsoft's new Windows 3.1 operating environment, the two companies severed the relationship in 1992 and OS/2 development fell to IBM exclusively. The name stands for "Operating System/2", because it was introduced as part of the same generation change release as IBM's "Personal System/2 (PS/2)" line of second-generation personal computers. The first version of OS/2 was released in December 1987 and newer versions were released until December 2001.

OS/2 was intended as a protected-mode successor of PC DOS. Notably, basic system calls were modeled after MS-DOS calls; their names even started with "Dos" and it was possible to create "Family Mode" applications – text mode applications that could work on both systems. Because of this heritage, OS/2 shares similarities with Unix, Xenix, and Windows NT.

IBM discontinued its support for OS/2 on 31 December 2006. Since then, OS/2 has been developed, supported and sold by two different third-party vendors under license from IBM – first by Serenity Systems as eComStation since 2001, and later by Arca Noae LLC as ArcaOS since 2017.