DMC Sinai-Grace Hospital is the largest of the eight hospitals that comprise the Detroit Medical Center. Located in northwest Detroit, Sinai-Grace provides health care services in over 40 specialties and has 334 inpatient beds, is a full-service hospital including comprehensive cardiac care, stroke, surgical intensive care, medical intensive care, trauma and emergency medicine, cancer treatment, general and robotic surgeries, women's health, urology, gastrointestinal, gerontology, obstetrics/gynecology and cosmetic/plastic surgery. Sinai-Grace's Joint Excel Plus program features a minimally invasive knee and hip replacement surgery. Sinai-Grace also operates more than 25 outpatient care sites and ambulatory surgery centers throughout Wayne and Oakland Counties. Sinai-Grace is one of 10 hospitals in the nation to be awarded a Robert Wood Johnson Foundation grant to set the standards of cardiac care for hospitals and physicians throughout the nation. U.S. News & World Report named Sinai-Grace Hospital as high performing in 2 adult procedures and conditions.

More than 200 medical students and resident physicians in a variety of medical and surgical specialties get their advanced training at Sinai-Grace every year. In addition, nursing and medical students, radiology technicians, pharmacists, physician assistants, pathologists' assistants, and chaplains train at the hospital.