Science Policy Research Unit (SPRU) is a research centre based at University of Sussex in Falmer, near Brighton, UK. It focuses on long term transformative change, science policy and innovation across different sectors, societies and structures. It was one of the first interdisciplinary research centres in the field of science and technology policy and at the forefront of the development of innovation as an academic discipline. Alongside internationally renowned research, SPRU also offers a range of MSc courses, as well as PhD research degrees.

SPRU's research today addresses pressing global policy agendas, including the future of industrial policy, inclusive economic growth; the politics of scientific expertise, energy policy, security issues, entrepreneurship, and pathways to a more sustainable future. It aims to tackle real-world questions whilst also contributing to theoretical knowledge on innovation. In 2018, SPRU ranked 3rd in the world and 1st in the UK for top science and technology think tanks on the Global Go ToThink Tank Index Report which was put together by the University of Pennsylvania.

SPRU has 60 plus faculty members and more than 150 MSc and 50 doctoral students. With an extensive global alumni network among senior science and technology policy makers, SPRU is committed to engagement and generating impact at all stages of research. Members of SPRU work closely with government and parliament, think tanks, media, business and the third sector, and are experienced in disseminating and applying their latest research findings.