| Shri Shankaracharya Engineering College | Academic & Science |
| Shirdi Sai Engineering College (India) | Academic & Science |
| Sri Sairam Engineering College (est. 1995; India) | Academic & Science |
| Shantilal Shah Engineering College | Academic & Science |
| Senior System Engineering Council | Academic & Science |
| Sound Surveillance Evaluation Center | Academic & Science |
| Surface Ship Engineering Center | Academic & Science |
| Solid State Electronics Center (Honeywell) | Academic & Science |
| Small Signal Equivalent Circuit | Academic & Science |
| Space Science and Engineering Center | Academic & Science |
| Southernmost Branch of the South Equatorial Current | Academic & Science |
| SKA (Square Kilometre Array) Science and Engineering Committee | Academic & Science |
| Society for the Study of Early Christianity | Academic & Science |
| Student Section Executive Committee | Academic & Science |
| Student Stock Exchange Concilium (McGill University) | Academic & Science |
| Solid State Equipment Corporation (Horsham, PA) | Business |
| Southwest Systems Engineering Corporation (est. 1991; Sierra Vista, AZ) | Business |
| Suzhou Samsung Electronics Co., Ltd. (China) | Business |
| Sinopec Shanghai Engineering Company Limited (China) | Business |
| Shanghai Stock Exchange Composite (index; China) | Business |
| South Seas Evangelical Church | Community |
| South Sea Evangelical Church (Solomon Islands) | Community |
| Source Selection Evaluation Committee | Community |
| Stepping Stone Educational Centre | Community |
| South Shore Educational Collaborative (Hingham, MA) | Community |
| Singapore Standard Educational Classification (Singapore) | Community |
| Society for the Study of Early China | Community |
| Social Science Education Consortium | Community |
| Secondary Schools Examinations Council | Community |
| Soft Sector | Computing |
| Selective Sequence Electronic Calculator | Computing |
| Static Source Error Correction | General |
| Structural Steel Educational Council | Governmental |
| Santé, Sécurité, Environnement et Communauté (French: Health, Safety, Environment and Community) | Governmental |
| Southern Solar Energy Center | Governmental |
| Solar System Exploration Committee (NASA) | Governmental |
| Sutherland Shire Environment Centre (Australia) | Regional |
| Society for the Study of Early Christianity (Australia) | Regional |
| Sarnia Sports and Entertainment Centre (Canada) | Regional |
| Singlespeed European Championship (bicycle race) | Regional |
| Saigon Sky Exhibition Center (Ho Chi Minh City, Vietnam) | Regional |
| Scottish Social Enterprise Coalition | Regional |
| Sarnia Sports & Entertainment Centre | Sports |
