Tamale Senior High School formerly Government Secondary School, Tamale, Gbewaa Secondary School, and more recently Tamale Secondary School is a co-educational second cycle boarding school located at Education Ridge, a suburb of the Sagnarigu Municipality (which was carved out of the Tamale Metropolis in 2012) in the Northern Region of Ghana. The school was founded in 1951 by the then British Colonial Authorities as the first second cycle institution of the Northern Territories.

The school is a selective school that grants admissions to students in Ghana based on their results in the Basic Education Certificate Examination, and for students outside Ghana, based on a special entrance examination prepared by the school. Courses offered by the school include; Business, General Science, Home Economics, Technical, General Arts, and Visual Arts.

Tamale Senior High School is considered amongst institutions of the highest prestige in Ghana, due to its longstanding history predating independent Ghana, and its prominent alumni. The school can count amongst its ranks; a head of State, two vice presidents of the fourth republic of Ghana, a speaker of parliament, two Justices of the Supreme Court of Ghana, two Chiefs of Defence Staff, and a host of government ministers and members of parliament.