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Cobicistat, sold under the brand name Tybost, is a medication for use in the treatment of human immunodeficiency virus infection (HIV/AIDS). Its major mechanism of action is through the inhibition of human CYP3A proteins.

Like ritonavir (Norvir), cobicistat is of interest for its ability to inhibit liver enzymes that metabolize other medications used to treat HIV, notably elvitegravir, an HIV integrase inhibitor. By combining cobicistat with elvitegravir, higher concentrations of the latter are achieved in the body with lower dosing, theoretically enhancing elvitegravir's viral suppression while diminishing its adverse side-effects. In contrast with ritonavir, the only other booster approved for use as a part of HAART, cobicistat has no anti-HIV activity of its own.

Cobicistat is a component of three four-drug, fixed-dose combination HIV treatments. The first, elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil, is marketed as Stribild and was approved by the FDA in August 2012 for use in the United States. The second, elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide, is marketed as Genvoya and was approved by the FDA in November 2015 for use in the United States. Both Stribild and Genvoya are owned by Gilead Sciences. The third, cobicistat, darunavir, emtricitabine, and tenofovir alafenamide, is marketed as Symtuza and was FDA approved July 17, 2018 and is owned by Janssen Pharmaceuticals.

Additionally, in existence are a fixed-dose combination of cobicistat and protease inhibitor darunavir (darunavir/cobicistat; marketed as Prezcobix by Janssen Therapeutics), and a fixed-dose combination of cobicistat and protease inhibitor atazanavir (atazanavir/cobicistat; marketed as Evotaz by Bristol-Myers Squibb). Both Prezcobix and Evotaz were approved by the FDA in January 2015.

Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir, and tenofovir alafenamide.

INFO: Full form for THEDS is Tower Hamlets Early Detection Service in Medical category

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INFO: Full form for THELMA is Transactional Health Exchange Linking Multiple Applications in Medical category

INFO: Full form for PMBT is Primary Malignant Brain Tumors in Medical category
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INFO: Full form for BDDA is BisDehydroDoisynolic Acid in Medical category
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INFO: Full form for PMBT is Precision Muscle Balancing Technology in Medical category
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A disability is any condition that makes it more difficult for a person to do certain activities or effectively interact with the world around them (socially or materially). These conditions, or impairments, may be cognitive, developmental, intellectual, mental, physical, sensory, or a combination of multiple factors. Impairments causing disability may be present from birth or can be acquired during a person's lifetime. The United Nations Convention on the Rights of Persons with Disabilities defines disability as:

long-term physical, mental, intellectual or sensory impairments which in interaction with various barriers may hinder [a person's] full and effective participation in society on an equal basis with others.

Disability is a contested concept, with shifting meanings in different communities. It has been referred to as an "embodied difference," but the term may also refer to physical or mental attributes that some institutions, particularly medicine, view as needing to be fixed (the medical model). It may also refer to limitations imposed on people by the constraints of an ableist society (the social model); or the term may serve to refer to the identity of disabled people. Physiological functional capacity (PFC) is a measure of an individual's performance level that gauges one's ability to perform the physical tasks of daily life and the ease with which these tasks are performed. PFC declines with age and may result to frailty, cognitive disorders, or physical disorders, all of which may lead to labeling individuals as disabled. According to the World Report on Disability, 15% of the world's population or 1 billion people are affected by disability. A disability may be readily visible, or invisible in nature.

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Tenosynovial giant cell tumor (TGCT) is a group of rare, typically non-malignant tumors of the joints. TGCT tumors often develop from the lining of joints (also known as synovial tissue).: 100 : 245 

Common symptoms of TGCT include swelling, pain, stiffness and reduced mobility in the affected joint or limb.: 102 This group of tumors can be divided into different subsets according to their site, growth pattern, and prognosis.: 361 Localized TGCT is sometimes referred to as giant cell tumor of the tendon sheath;: 100 diffuse TGCT is also called pigmented villonodular synovitis (PVNS).: 102 

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INFO: Full form for WNFV is West Nile Fever Virus in Medical category

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The Royal Hobart Hospital is a public hospital in the Hobart CBD, Tasmania, Australia. The hospital also functions as a teaching hospital in co-operation with the University of Tasmania. The hospital's research facilities are known as the Royal Hobart Hospital Research Foundation. Also close to the hospital site is the Menzies Research Institute.

The hospital is run by the Tasmanian Government as part of the Department of Health and Human Services and is the largest hospital, and the largest employer, in Tasmania. The hospital provides services for all of southern Tasmania and has capacity for 400 patients. Many statewide services such as cardiothoracic surgery, neurosurgery, major trauma, high-risk obstetrics, hyperbaric medicine, and neonatal intensive care are based at the hospital, with referrals coming in from the north and northwest.

The main entrance underwent construction for a new underground emergency department. This began operation in early 2007 with surrounding construction ongoing. A more recent hospital redevelopment project was initiated with A$565 million in funding, including a new women's and children's precinct, cancer service, intensive care unit, and day surgery facility.

Orlando Regional Medical Center (ORMC) is an 808-bed tertiary hospital in downtown Orlando, Florida designed by HKS, Inc. (architect) and Walter P Moore (structural engineer). It is the flagship of the Orlando Health system.

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The ambulatory (Latin: ambulatorium, ‘walking place’) is the covered passage around a cloister or the processional way around the east end of a cathedral or large church and behind the high altar. The first ambulatory was in France in the 11th century but by the 13th century ambulatories had been introduced in England and many English cathedrals were extended to provide an ambulatory.

The same feature is often found in Indian architecture and Buddhist architecture generally, especially in older periods. Ritual circumambulation or parikrama around a stupa or cult image is important in Buddhism and Hinduism. Often the whole building was circumambulated, often many times. The Buddhist chaitya hall always allowed a path for this, and the Durga temple, Aihole (7th or 8th century) is a famous Hindu example.

The term is also used to describe a garden feature in the grounds of a country house. A typical example is the one shown, which stands in the grounds of Horton Court in Gloucestershire, England.

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