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Multiple sequence alignment (MSA) may refer to the process or the result of sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In many cases, the input set of query sequences are assumed to have an evolutionary relationship by which they share a linkage and are descended from a common ancestor. From the resulting MSA, sequence homology can be inferred and phylogenetic analysis can be conducted to assess the sequences' shared evolutionary origins. Visual depictions of the alignment as in the image at right illustrate mutation events such as point mutations (single amino acid or nucleotide changes) that appear as differing characters in a single alignment column, and insertion or deletion mutations (indels or gaps) that appear as hyphens in one or more of the sequences in the alignment. Multiple sequence alignment is often used to assess sequence conservation of protein domains, tertiary and secondary structures, and even individual amino acids or nucleotides.

Computational algorithms are used to produce and analyse the MSAs due to the difficulty and intractability of manually processing the sequences given their biologically-relevant length. MSAs require more sophisticated methodologies than pairwise alignment because they are more computationally complex. Most multiple sequence alignment programs use heuristic methods rather than global optimization because identifying the optimal alignment between more than a few sequences of moderate length is prohibitively computationally expensive. On the other hand, heuristic methods generally fail to give guarantees on the solution quality, with heuristic solutions shown to be often far below the optimal solution on benchmark instances.

INFO: Full form for MSA is Multi System Atrophy in Medical category
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INFO: Full form for MSA is Metabolic Stone Analysis in Medical category
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INFO: Full form for MSA is Medical Services of America in Medical category
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INFO: Full form for NIM is Neural Impulse Maximizer in Medical category
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A multiple of the median (MoM) is a measure of how far an individual test result deviates from the median. MoM is commonly used to report the results of medical screening tests, particularly where the results of the individual tests are highly variable.

MoM was originally used as a method to normalize data from participating laboratories of Alpha-fetoprotein (AFP) so that individual test results could be compared. 35 years later, it is the established standard for reporting maternal serum screening results.

An MoM for a test result for a patient can be determined by the following:

As an example, Alpha-fetoprotein (AFP) testing is used to screen for a neural tube defect (NTD) during the second trimester of pregnancy. If the median AFP result at 16 weeks of gestation is 30 ng/mL and a pregnant woman's AFP result at that same gestational age is 60 ng/mL, then her MoM is equal to 60/30 = 2.0. In other words, her AFP result is 2 times higher than "normal."

INFO: Full form for MOM is Millennium Occupational Medicine in Medical category
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INFO: Full form for RMI is Recent Myocardial Infarction in Medical category
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INFO: Full form for RMI is Regional Medical Imaging in Medical category
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INFO: Full form for RMI is Reperfused Myocardial Infarction in Medical category
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INFO: Full form for RMI is Risk of Malignancy Index in Medical category
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INFO: Full form for AMPS is Alignment of Multiple Protein Sequences in Medical category
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